In contrast, anti-oxidants failed in clinical trials and the dogma was shattered. By now, rapamycin has been proven to be an anti-aging drug. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.Īt first, the discovery of anti-aging properties of rapamycin was met with skepticism because it challenged the dogma that aging is a decline driven by molecular damage caused by free radicals. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Received: FebruAccepted: ApPublished: Abstract Keywords: lifespan, longevity, rejuvenation, health, diseases 1 Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
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